As with many substances, some users have reported tolerance to kratom after using it on a regular basis. This often leads to the case in which the individual needs to consume more Kratom to get the desired effect. Each user's experience is unique, and so is their tolerance. However, there are some tips to keep your Kratom tolerance low.
Before we start, we need to get a bit technical. Kratom contains two main components called alkaloids (hydroxymitragynine) and metabolites (mitragyna). When these substances are present in the bloodstream they get to the brain where they act on the neuro-receptors and produce the physical effects you know and love. If any other substances binds to the receptors before Kratom’s metabolites and alkaloids, it would prevent our body from experiencing the effects of Kratom.
Our first advice would be to never mix Kratom with any other substance because you can get into a vicious circle of consuming a higher dose to get the desired effect and tampering your tolerance levels. Following this line, if you want to keep your tolerance down, you should stick with small amounts of Kratom. If you take opioids or Kratom regularly, the sensitivity of the receptors on your brain may change, that is, the receptors become less sensitive and then you would need consume more kratom in order to achieve the same feeling and end up in the same vicious circle we just mentioned.
How to overcome tolerance to kratom
Give it time and keep it low. Opt for small doses of Kratom and stretch them for a generous amount of time. The key is to find the point between minimum quantity you need and maximum time range to get the desired effect.
Take a break: Time cures everything, including neuro-receptors. Stop using Kratom for a couple of days or weeks. Over time, the receptors will return to their natural state. And when you resume consuming kratom, your brain will react as if it were the first time.
Mix it up: Try using a different type of Kratom. There is a phenomenon that some call "single strain syndrome," which appears to occur when the body gets used to the components found in a specific variety of kratom.
Include natural inhibitors in your diet: Grape seed extract and ginseng are believed to have enzymes that help reduce the amount of kratom that is absorbed by the body and that contribute to reset your neuro-receptors. This is not yet proven by science, but it does not hurt to try.
Get experimental: According to the study “Curcumin Attenuates Opioid Tolerance and Dependence by Inhibiting Ca2+/Calmodulin-Dependent Protein Kinase II α Activity” published by The Journal of Pharmacology and Experimental Therapeutics on 2015, Tumeric contains a compound (curcumin) that is capable of suppressing and even reversing tolerance to opioids such as Kratom. You would need significant amounts of it to lower tolerance to Kratom, so a curcumin supplement would be a better choice.
Try these tips and trust your body and mind. Want to know more about Kratom? Give us a call at (786) 766-0111.